Abstract
The response of epithelial cells of the small intestine and cornea to administration of colchicine at different times of day and night was studied in mice. Colchicine, made up in physiological saline, was injected subcutaneously into the animals in a dose of 1 mg/kg at 7 a.m. and 7 p.m. Mice of the control group received physiological saline. The animals were killed 2 h after each injection. After injection of the alkaloid in the evining the stathmokinetic effect in the intestinal epithelium was more marked than after the morning injection. In the corneal epithelium the diurnal variations in the stathmokinetic reaction were less marked and were classed chiefly as metaphase delay.
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Semenova, N.F. Diurnal variations in the response of intestinal and corneal epithelial cells of mice to colchicine. Bull Exp Biol Med 78, 1408–1410 (1974). https://doi.org/10.1007/BF00808719
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DOI: https://doi.org/10.1007/BF00808719