Abstract
Immunoglobulins covering the surface of leukemic cells in the initial stage of Rauscher's leukemia in vivo and detectable in eluates from spleen cells of C57BL/6 and BALB/c mice, and also eluates of serum 7S-antibodies, when tested in vitro, block the cytotoxic effect of isologous and homologous 19S-antibodies against the group-specific antigen of mouse leukemic cells. The blocking antibodies (7S-IgG) isolated from both sources possess similar biological activity by stimulating the development of leukemia in experiments in vivo.
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Ter-Grigorov, V.S., Dzagurov, S.G. & Shevelev, B.I. In vitro blocking activity and biological effect of IgG (7S-antibodies) isolated from spleen cells and serum of mice developing Rauscher's leukemia. Bull Exp Biol Med 78, 1395–1398 (1974). https://doi.org/10.1007/BF00808715
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DOI: https://doi.org/10.1007/BF00808715