Abstract
Experiments on decerebrate cats showed that fentanyl, in a dose of 10 μg/kg or more, inhibits neurons of the bulbar respiratory center, with a resulting decrease in the mean firing rate, a change in the number of spikes in the discharge and its duration, and disturbance of the temporal distribution of spikes in the discharge. The degree of inhibition of the inspiratory neurons depends on the initial firing rate. Inhibition of activity of the expiratory neurons is more pronounced.
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Vinogradov, A.V., Dmitriev, A.V. & Ignatov, Y.D. Effect of fentanyl on single unit activity in the bulbar respiratory center. Bull Exp Biol Med 78, 1375–1378 (1974). https://doi.org/10.1007/BF00808709
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DOI: https://doi.org/10.1007/BF00808709