Summary
Enantiomerically pureα-substitutedβ-amino acids have been synthesized, the key step being the diastereoselective alkylation of aβ-alanine derivative with two chiral handles (1S,2R,5S)-menthyl N-[(1S,2S,5S)-2-hydroxypinan-3-ylidene]β-alaninate.
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Akssira, M., Boumzebra, M., Kasmi, H. et al. Asymmetric synthesis ofα-substitutedβ-amino acids using aβ-alanine derivative with two chiral handles. Amino Acids 7, 79–81 (1994). https://doi.org/10.1007/BF00808448
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DOI: https://doi.org/10.1007/BF00808448