Abstract
The antiphosphodiesterase preparation 1-methyl-3-isobutylxanthine (MIBX) inhibited anaphylactic reactionsin vitro andin vivo: It inhibited the anaphylactic liberation of histamine from isolated rat mast cells, the anaphylactic contraction of the isolated guinea pig trachea, the passive cutaneous anaphylactic reaction (PCAR) in mice, and anaphylactic bronchospasm (AB) in guinea pigs. The MIBX inhibited the anaphylactic reaction of the trachea, PCAR, and AB to a greater degree than the corresponding reactions induced by histamine.
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Gushchin, I.S., Bogush, N.L. & Sviridov, V.V. Inhibition of anaphylactic reactionsin vitro andin vivo by 1-methyl-3-isobutylxanthine. Bull Exp Biol Med 83, 520–523 (1977). https://doi.org/10.1007/BF00807494
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DOI: https://doi.org/10.1007/BF00807494