Abstract
The reaction of piperidine with formaldehyde over γ-alumina, Na+-γ-alumina, NiAl2O4 and CuAl2O4 was studied as a model system in order to understand the mechanism and selectivity of alkylpyridine formation from piperidine and carbonyl compounds. Along with the expected 3-picoline, 2-picoline and other products were also formed. The selectivity for 3-picoline was high on γ-alumina whereas on NiAl2O4, 2-picoline was selectively formed. The formation of the different products has been rationalized and a probable mechanism for the formation of 2-picoline has been presented.
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Kameswari, U., Pillai, C.N. Reaction of piperidine with formaldehyde over alumina and spinel aluminates. Catal Lett 38, 53–56 (1996). https://doi.org/10.1007/BF00806899
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DOI: https://doi.org/10.1007/BF00806899