Abstract
A comparative investigation of the erythrocytes of mice differing in their original susceptibility to spontaneous carcinogenesis of the mammary gland revealed characteristic deformation of the cells (echinocytosis) in C3H mice with a well-marked predisposition to cancer. The number of erythrocytes with spinous projections was 58.6% in the early pretumor period (age 3–4 months) and reached 91.1% in the late pretumor period (11–12 months). In intact C57BL/6 mice resistance to mammary gland carcinogenesis the number of echinocytes at the same age periods varied from 16 to 18.7%. Growth of tumors (spontaneous in C3H mice and transplanted Ehrlich's adenocarcinoma in C57BL/6 mice) was accompanied by an increase in the number of echinocytes and in the degree of severity of the echinocytosis (96.6 and 65.3% respectively). The possible mechanisms of the pathogenesis of echinocytosis during carcinogenesis are discussed.
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Kashulina, A.P., Tereshchenko, I.P. State of the erythrocyte surface (echinocytosis) in experimental carcinogenesis. Bull Exp Biol Med 87, 476–478 (1979). https://doi.org/10.1007/BF00806688
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DOI: https://doi.org/10.1007/BF00806688