Abstract
The authors described previously local intercellular interactions inhibiting the growth of the number of antibody-forming cells (AFC) in a suspension of spleen cells from unimmunized mice and increasing sharply with an increase in the density of cultured suspensions. The present investigation shows that preliminary immunization of mice with an antigen abolishes or greatly weakens the inhibition of the increase in the number of AFC relative to that particular antigen, but does not affect the inhibition of the increase in the number of cells forming antibodies against another antigen or inhibition of proliferation of the main mass of dividing cells in culture.
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Grigor'eva, O.S., Korukova, A.A. & Gurvich, A.E. Immunologic specificity of local inhibitory intercellular interactions. Bull Exp Biol Med 85, 761–763 (1978). https://doi.org/10.1007/BF00806158
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DOI: https://doi.org/10.1007/BF00806158