Abstract
The effect of subcutaneous injection of the immunosuppressive agent methylene-diphosphonic acid (MDPA) on hypersensitivity of delayed and immediate types (HDT and HIT) was studied in guinea pigs. Administration of MDPA to the animals in a dose of 30 μg/g was found to inhibit HDT and HIT by 60–80% compared with the control.
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Laboratory of Immunochemistry, A. V. Palladin Institute of Biochemistry, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Byulleden' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 339–341, September, 1977.
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Komissarenko, S.V., Zhuravskii, N.I., Karlova, N.P. et al. Inhibition of hypersensitivity of delayed and immediate types in guinea pigs by methylenediphosphonic acid. Bull Exp Biol Med 84, 1322–1323 (1977). https://doi.org/10.1007/BF00805896
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DOI: https://doi.org/10.1007/BF00805896