Abstract
After destruction or removal of part of the liver in rats the levels of antithrombins II, III, and IV fell proportionally to the extent of the interference. Destruction of the spleen led to depression, but splenectomy led to activation of antithrombin IV. Blockade of the reticuloendothelial system caused a smaller decrease in the antithrombin level than partial hepatectomy. It is suggested that the spleen produces an inhibitor of antithrombin IV.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. P. Babich and A. Sh. Byshevskii, Lab. Delo, No. 8, 467 (1972).
T. N. Gorshkova and A. A. Markosyan, in: Heparin. Physiology, Biochemistry, Pharmacology, and Clinical Application [in Russian], Leningrad (1969), pp. 62–64.
L. V. Mikhailova and A. Sh. Byshevskii, Byull. Éksp. Biol. Med., No. 5, 16 (1969).
V. E. Pastorova et al., Byull. Éksp. Biol. Med., No. 11, 23 (1961).
H. H. Henstell et al., Proc. Soc. Exp. Biol. (New York),122, 247 (1966).
L. T. Mann et al., Science,166, 517 (1969).
Rights and permissions
About this article
Cite this article
Babich, V.P. Antithrombin activity after blockage of the reticuloendothelial system, splenectomy, and partial hepatectomy. Bull Exp Biol Med 84, 1249–1251 (1977). https://doi.org/10.1007/BF00805874
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00805874