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Role of macrophages in the mechanism of specific retention of sensitized lymphocytes in lymph glands containing antigen

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The role of macrophages in the phenomenon of specific retention of antigen-activated. lymphocytes in lymph glands containing the same antigen was investigated. Injection of peritoneal macrophages, phagocytosing sheep's red cells (as well as of the red cells alone) was found to cause specific retention of lymphocytes in the regional lymph glands. Preliminary treatment of the antigen-loaded macrophages with antierythrocytic serum reduced the retention of lymphocytes. It is postulated that lymphocytes are fixed by means of receptors on their surface to the membrane of macrophages, into which antigen molecules are incorporated.

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Authors
  1. V. V. Malaitsev
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  2. V. P. Zakharova
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  3. L. V. Van'ko
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  4. B. B. Fuks
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Malaitsev, V.V., Zakharova, V.P., Van'ko, L.V. et al. Role of macrophages in the mechanism of specific retention of sensitized lymphocytes in lymph glands containing antigen. Bull Exp Biol Med 81, 410–412 (1976). https://doi.org/10.1007/BF00804934

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  • DOI: https://doi.org/10.1007/BF00804934

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