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Mechanism of action of nonachlazine on nervous control over the coronary circulation

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The new antiaginal drug nonachlazine, in experiments on anesthetized cats and dogs, inhibited the response of reflex decrease of the blood flow into the coronary arteries. In freely behaving cats nonachlazine also inhibited reflex changes in the blood flow in the system of the common carotid artery and reduced pressor vasomotor reflexes. Nonachlazine selectively inhibited vasoconstrictor impulses from Aδ-afferent fibers of spinal nerves, i.e., it acts on the vasomotor component of the “primary” nociceptive response. This mechanism may perhaps lie at the basis of the relief of the pain syndrome by nonachlazine in ischemic heart disease.

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Authors
  1. É. A. Bendikov
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  2. T. S. Gan'shina
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Bendikov, É.A., Gan'shina, T.S. Mechanism of action of nonachlazine on nervous control over the coronary circulation. Bull Exp Biol Med 81, 375–378 (1976). https://doi.org/10.1007/BF00804924

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  • DOI: https://doi.org/10.1007/BF00804924

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