Abstract
Behavioral and EEG manifestations of leptazol convulsions were studied in freely moving rats after preliminary destruction of the striatum. Although the operation did not appreciably disturb the spike-wave activity, it interfered greatly with the provocation of myoclonic convulsions and their conversion into tonicoclonic convulsions. The threshold, duration, and severity of the fit also were increased and status epilepticus actually developed in 50% of rats. Striatectomy abolished the action of catecholaminergic drugs (apomorphine, dopa, haloperidol, chlorpromazine) on the thresholds of myoclonic spasms and convulsions. The important role of the striatum in the formation of the motor manifestations of leptazol convulsions and in the arrest of the generalized fit is emphasized.
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Avakyan, R.M. Effect of striatectomy on the course of leptazol convulsions in rats. Bull Exp Biol Med 81, 371–374 (1976). https://doi.org/10.1007/BF00804923
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DOI: https://doi.org/10.1007/BF00804923