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Antibody formation against antigen-recognizing receptors of T lymphocytes in a syngeneic system

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Antibody formation against antigen-recognizing receptors of T lymphocytes were shown to be capable of being formed in a syngeneic system. Antiserum of CBA mice receiving intravenous injections of CBA lymphocytes immune against C57BL cells specifically inhibited blast transformation of CBA T lymphocytes against C57BL cells only in a mixed culture. The same antiserum had no effect on proliferative actiivy of CBA T lymphocytes reacting to “foreign antigen” — i.e., DBA/2 cells. No antibodies against C57BL cells likewise were found in the antireceptor antiserum. A regulatory influence of autoantireceptor antibodies on the immune response is postulated.

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Authors
  1. V. G. Nesterenko
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  2. I. Yu. Chernyakhovskaya
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Nesterenko, V.G., Chernyakhovskaya, I.Y. Antibody formation against antigen-recognizing receptors of T lymphocytes in a syngeneic system. Bull Exp Biol Med 84, 1731–1734 (1977). https://doi.org/10.1007/BF00804820

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  • DOI: https://doi.org/10.1007/BF00804820

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