Some mechanisms of the different effects of sucrose on the blood and liver lipid levels in experimental animals

Abstract

Experiments on rats showed that inclusion of sucrose in the composition of diets with a high or normal carbohydrate content accelerates synthesis of apoproteins of pre-β-lipoproteins in the liver and their loading with endogenously formed lipids and facilitates the more rapid secretion of very-low-density lipoproteins (VLDLP) into the blood stream and a raised blood triglyceride level. However, the rate of complex formation between lipids and protein of the pre-β-lipoproteins in the liver also depends on the relative proportions of the carbohydrate and lipid components in the diet. On a diet with sucrose in which the ratio between carbohydrates and fats is physiological (2∶1), a lower level of lipid loading of the apoproteins of pre-β-lipoproteins is found, with a consequent increase in the lipid content in the liver.