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Effect of hyperthermia on the rate of elimination of I131 from the thyroid gland and the body

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In rats exposed to hyperthermia, besides inhibition of the iodine-concentrating mechanism in the thyroid gland, the intrathyroid hormonal fractions are mobilized and their internal deiodination takes place intensively, nonhormonal iodine is actively discharged from the gland, and the elimination of extrathyroid iodine is stimulated. Exposure of man to hyperthermia gives a qualitatively similar effect. Transient hyperthermia after the accumulation of radio-iodine by the thyroid gland reduces the absorbed dose for the thyroid gland and the body as a whole appreciably and it can be regarded as a promising constituent of the combined treatment of radioiodine poisoning.

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Literature Cited

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Authors
  1. V. E. Zaichik
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  2. B. D. Pavlov
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  3. A. V. Tkachev
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Zaichik, V.E., Pavlov, B.D. & Tkachev, A.V. Effect of hyperthermia on the rate of elimination of I131 from the thyroid gland and the body. Bull Exp Biol Med 78, 1143–1146 (1974). https://doi.org/10.1007/BF00804620

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  • DOI: https://doi.org/10.1007/BF00804620

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