Abstract
A study of submicroscopic changes in astrocytes after intracerebral injection of the carcinogen 9,10-dimethyl-1,2-benzanthracene suggests that the so-called true period of preglioma begins on the 45th day of the experiment, when astrocytes of a typical ultrastructure begin to appear against the background of degenerative changes. Changes in the submicroscopic organization of the astrocytes during chemical carcinogenesis can be subdivided into three stages: I) intracellular hyperplasia, due to traumatic brain injury; II) degenerative changes, connected with disturbance of the blood supply to the tissue and the direct action of the carcinogen on it; III) atypical ultrastructural reorganization.
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Abdullakhodzhaeva, M.S., Ibragimov, T.K. Ultrastructural aspects of preglioma. Bull Exp Biol Med 87, 384–387 (1979). https://doi.org/10.1007/BF00804430
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DOI: https://doi.org/10.1007/BF00804430