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Dynamics of changes in brain glucose-6-phosphate dehydrogenase activity under the influence of trifluoperazine and fluacizine

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The dynamics and localization of glucose-6-phosphate dehydrogenase activity in the various structures of the brain was studied histochemically in experiments on rats after a single or repeated injection of the neuroleptic trifluoperazine and the antidepressant fluacizine. Both preparations were shown to modify the enzyme activity in many brain formations.

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Literature Cited

  1. V. A. Markin and V. S. Mitrofanov, Farmakol. i Toksikol., No. 6, 669 (1970).

    Google Scholar 

  2. V. A. Markin and V. S. Mitrofanov, Farmakol. i Toksikol., No. 6, 659 (1971).

    Google Scholar 

  3. V. A. Markin and V. S. Mitrofanov, Byull. Éksperim. Biol. i Med., No. 1, 43 (1971).

    Google Scholar 

  4. G. S. Khachatryan, in: Abstracts of Sectional Proceedings of the 5th International Biochemical Congress [in Russian], Vol. 1, Moscow (1961), p. 475.

  5. G. S. Khachatryan, Biochemistry of the Brain under Normal Physiological Conditions. The Hexose Monophosphate Shunt [in Russian], Erevan (1967).

  6. A. Burt and B. Wenger, Develop. Biol.,3, 84 (1961).

    Google Scholar 

  7. M. Carver, Biochem. Pharmacol.,12, 19 (1963).

    Google Scholar 

  8. S. Hotta, J. Neurochem.,9, 43 (1962).

    Google Scholar 

  9. S. Hotta, and J. Seventko, Arch. Biochem.,123, 104 (1968).

    Google Scholar 

  10. R. Wegmann and G. Gerzeli, Ann. Histochim.,6, 111 (1961).

    Google Scholar 

  11. M. Wollemann, Agressologie,4, 605 (1963).

    Google Scholar 

  12. M. Wollemann and H. Laborit, Agressologie,9, 91 (1968).

    Google Scholar 

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Markin, V.A., Mitrofanov, V.S. Dynamics of changes in brain glucose-6-phosphate dehydrogenase activity under the influence of trifluoperazine and fluacizine. Bull Exp Biol Med 78, 1286–1289 (1974). https://doi.org/10.1007/BF00804361

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  • DOI: https://doi.org/10.1007/BF00804361

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