Abstract
A trigeminal pain syndrome was produced in experiments on albino rats by injecting tetanus toxin into the caudal nucleus of the spinal tract of the trigeminal nerve. Tetanus toxin was used as a substance disturbing inhibition. The syndrome described has the characteristic features of the clinically familar trigeminal neuralgia. It is concluded that this syndrome of experimental trigeminal neuralgia is based on the formation of a generator of pathologically increased excitation (a pathological dispatch station) in the system of the caudal nucleus of the trigeminal nerve as a result of the disturbance of inhibition. Mechanisms similar in principle, a disturbance of inhibition and the formation of excitation generators in the corresponding parts of the CNS, are considered to lie at the basis of various pain syndromes.
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Laboratory of Pathophysiology of Toxico-Infections. Institute of Normal and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byullenten' Éksperimental'noi Biologii i Meditsiny, Vol. 78, No. 11, pp. 16–20, November, 1974.
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Kryzhanovskii, G.N., Igon'kina, S.I., Grafova, V.N. et al. Experimental trigeminal neuralgia (the concept of the generator mechanism of the pain syndrome). Bull Exp Biol Med 78, 1234–1237 (1974). https://doi.org/10.1007/BF00804343
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DOI: https://doi.org/10.1007/BF00804343