Abstract
The action of a supernatant obtained after extraction of a homogenate of the mucosa and submucosa of the human appendix with 95% acetone on the melanophores of the frog skin was investigated. A bleaching action was found, indicating that the homogenate contained melatonin. Considering the high content of the melatonin precursor, 5-hydroxytryptamine (serotonin), in the enterochromaffin cells, the possibility of melatonin biosynthesis in these cells during serotonin metabolism can be postulated.
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Raikhlin, N.T., Kvetnoi, I.M. Bleaching action of extract of the mucosa and submucosa of the human appendix on melanophores of the frog skin. Bull Exp Biol Med 78, 955–957 (1974). https://doi.org/10.1007/BF00803940
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DOI: https://doi.org/10.1007/BF00803940