Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 2, pp 895–897 | Cite as

Effect of hydrocortisone on the blood sugar and glycogenesis in rats with tumors

  • V. S. Shapot
  • V. A. Blinov
Biochemistry and Biophysics


In fasting control rats and rats with tumors most exogenous glucose-C14 is utilized for glycogen synthesis in the liver only during the first 3 h after administration of hydrocortisone. In fasting rats with Zajdela's hepatoma the threshold of sensitivity of the liver tissue to the induction of glycogen synthesis by hydrocortisone and to the final hyperglycemic effect of this hormone is raised. The substrate induction of glycogenesis in the liver is not disturbed in rats with tumors.

Key Words

glycogen synthesis liver hydrocortisone Zajdela's hepatoma 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • V. S. Shapot
    • 1
  • V. A. Blinov
  1. 1.Academy of Medical Sciences of the USSRUSSR

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