Abstract
The rate of hydroxylation of androgens was shown to be significantly reduced by γ-ray irradiation in doses of over 600 R. The rate of hydroxylation of estrogens showed little change. During irradiation under these conditions the content of cytochrome P-450 in the rat liver microsomes fell. The decrease in the rate of hydroxylation of steroid hormones by rat liver microsomes under the influence of whole-body γ-ray irradiation evidently depends on quantitative changes in cytochrome P-450.
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Department of Molecular Pharmacology and Radiobiology, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute.
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Khalilov, E.M., Bol'shev, V.N. Effect of whole-body γ-ray irradiation on the rate of steroid hormone hydroxylation by rat liver microsomes. Bull Exp Biol Med 81, 827–829 (1976). https://doi.org/10.1007/BF00802992
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DOI: https://doi.org/10.1007/BF00802992