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Enzyme thermosensitivity of leukocytes with trisomy for chromosome 21

  • Experimental Genetics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The thermosensitivity of glucose-6-phosphate dehydrogenase and myeloperoxidase was studied in lysates of leukocytes from patients with Down's syndrome. A statistically significant increase in temperature sensitivity of these two enzymes was discovered in leukocytes trisomic for chromosome 21 compared with the control. The differences observed may be based on an increased frequency of mutation injuries in the aberrant cells and also of abnormal post-translation modification of the protein molecules.

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Authors
  1. E. F. Davidenkova
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  2. E. I. Shvarts
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  3. K. N. Grinberg
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  4. M. P. Shafran
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Additional information

Academic Group of Corresponding Member of the Academy of Medical Sciences of the USSR Professor E. F. Davidenkova, Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad. Laboratory of Human Cytogenetics, Institute of Medical Genetics, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 1, pp. 41–44, January, 1979.

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Davidenkova, E.F., Shvarts, E.I., Grinberg, K.N. et al. Enzyme thermosensitivity of leukocytes with trisomy for chromosome 21. Bull Exp Biol Med 87, 49–51 (1979). https://doi.org/10.1007/BF00802351

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  • DOI: https://doi.org/10.1007/BF00802351

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