Abstract
Experiments on fibroblast-like Chinese hamster cells showed that agents inducing c-mitosis (colchicine, colcemid, low temperature) give rise to two distinct effects: stathmokinetic and radiomimetic. Toward the time of reversibility of the first of these effects, the second becomes clearly manifested as bridge formation. The appearance of this pathological form is evidently due to disturbance of cell nucleoprotein metabolism during c-mitosis.
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Boltovskaya, M.N., Strochkova, L.S., Starosvetskaya, N.A. et al. Pathology of mitosis after recovery of cells from metaphase block. Bull Exp Biol Med 87, 619–621 (1979). https://doi.org/10.1007/BF00801403
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DOI: https://doi.org/10.1007/BF00801403