Abstract
An allophenic mouse and three allophenic embryos were obtained by fusion of eight-cell Miwh/Miwh and +/+ embryos. The color of the hair and pigmented epithelium of the eye showed chimerism. The Miwh/Miwh melanoblasts die during development of the embryo. Variations in color of the chimera depend on interaction between normal melanocytes and the surrounding cells of the dermis, which consists of clones with the Miwh/Miwh or +/+ genotype and a mixture of cells of these genotypes. Differences were observed in the development of the right (chimeric) and left (normal) eyes and normal clones grew more rapidly in the allophenic mouse. Pigmentation of the eyes was reduced in the two allophenic embryos compared with normal. This indicates the autonomous action of the white gene in mice.
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Osipov, V.V., Vakhrusheva, M.P. Investigation of autonomy of action of the white gene in allophenic mice. Bull Exp Biol Med 85, 395–397 (1978). https://doi.org/10.1007/BF00801369
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DOI: https://doi.org/10.1007/BF00801369