Abstract
A study of tumor specific transplantation antigen (TSTA) on the cell membrane of SV40-induced tumors and spontaneous hepatomas of inbred Syrian hamsters and also of monkey cells infected in vitro with tsA-mutants of SV40 virus demonstrated its high temperature sensitivity. Heating the cells to 56°C for 30–60 min led to the total loss of their immunogenic activity. Moreover, in animals immunized by tumor cells heated to 56°C, stimulation of growth of the test tumor cells was regularly observed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Ya. M. Murka, Byull. Éksp. Biol. Med., No. 12, 11 (1965).
J. L. Anderson, R. G. Martin, C. Chang, et al., Virology,76, 254 (1977).
J. H. Coggin, V. M. Larson, and M. R. Hilleman, Proc. Soc. Exp. Biol. (New York),124, 774 (1967).
G. I. Deichman, T. E. Klychareva (Kluchareva), and W. L. Vendrov, in: Onco-Development Gene Expression, edited by W. H. Fishman and S. Sell, New York (1976), p. 337.
J. E. Morgan and C. P. Eng, Eur. J. Cancer,8, 293 (1972).
M. D. Prager, S. Der, A. Swaan, et al., Cancer Res.,31, 1488 (1971).
L. Reed and R. Muench, Am. J. Hyg.,27, 493 (1938).
Rights and permissions
About this article
Cite this article
Klyuchareva, T.E. Thermosensitivity of specific transplantation antigens of the tumor cell membrane. Bull Exp Biol Med 85, 378–380 (1978). https://doi.org/10.1007/BF00801364
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00801364