Abstract
Newborn albino mice were infected with three strains of enteroviruses and reinfected 6 weeks later with homologous or heterologous strains. Strains with relatively low pathogenicity for newborn mice were shown to lead to the formation of specific immunologic memory. If virus of high pathogenicity was used, prolonged production of specific antiviral antibodies and absence of a marked secondary immune response were observed in the surviving animals. Ability to produce interferon was independent of the pathogenicity of the strains for newborn animals and of the presence of antibodies against them.
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Priimyagi, L.S., Iyks, S.R. & Kul'berg, A.Y. Production of interferon and of virus-neutralizing antibodies in adult mice infected with enteroviruses in the neonatal period. Bull Exp Biol Med 85, 334–336 (1978). https://doi.org/10.1007/BF00801350
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DOI: https://doi.org/10.1007/BF00801350