Abstract
Rats with lateral hypothalamic self-stimulation (SS) were given morphine injections twice a day for 15 days in doses rising from 20 to 120 mg/kg. Morphine facilitated SS starting with the 9th injection. Short-term (16–18 h) withdrawal of the narcotic from the rats or its discontinuation led to inhibition of SS. Complete suppression of SS was observed after injection of the morphine antagonist nalorphine in a dose of 5 mg/kg.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
A. V. Val'dman, É. É. Zvartau, and M. M. Kozlovskaya, The Psychopharmacology of Emotions [in Russian], Moscow (1976).
I. N. Pyatnitskaya, Clinical Aspects of Narcotics [in Russian], Leningrad (1975).
W. J. Adams, S. A. Lorens, and C. L. Mitchell, Proc. Soc. Exp. Biol. (New York),140, 770 (1972).
H. D. Bush, M. F. Buch, M. A. Miller, et al., Physiol. Psychol.,4, 79 (1976).
R. Esposito and C. Kornetsky, Science,195, 189 (1977).
J. F. R. Konig and R. A. Klippel, The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem, Baltimore (1963).
S. A. Lorens and C. L. Mitchell, Psychopharmacologia (Berlin),32, 271 (1973).
R. Marcus and C. Kornetsky, Psychopharmacologia (Berlin),38, 1 (1974).
E. E. Zvartau, Res. Commun. Chem. Pathol. Pharmacol.,16, 707 (1977).
Rights and permissions
About this article
Cite this article
Zvartau, É.É. Hypothalamic self-stimulation in morphine-dependent rats during the abstinence syndrome. Bull Exp Biol Med 85, 321–324 (1978). https://doi.org/10.1007/BF00801347
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00801347