Abstract
Changes in the lactate dehydrogenase (LD) spectrum were studied by ultramicroelectrophoresis during development of mice: ripe ovum-zygote-blastocyst-embryo-oocyte-ripe ovum. In the cells of the embryo until the fifth day of development only H subunits of LD were found. The appearance of M subunits indicates derepression of the LD-A locus. On the eighth day of embryonic development the LD-B locus was derepressed. In the course of oogenesis the content of M subunits was reduced in the spectrum of the oocytes, a result of progressive repression of the LD-A locus. The dictyotene stage of the prophase of meiosis was characterized by active synthesis of H subunits and a gradual decrease in the synthesis of M subunits. The LD spectrum of the follicular cells throughout the stages of dictyotene was of the M type.
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Kolombet, L.V., Gapienko, E.F. Repression and derepression of lactate dehydrogenase loci in mice during development. Bull Exp Biol Med 83, 706–708 (1977). https://doi.org/10.1007/BF00800757
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DOI: https://doi.org/10.1007/BF00800757