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Specific suppression of the immune response in the adoptive transfer system

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Injection of spleen cells (SC) of syngeneic animals immunized with large doses of sheep's red cells (SRBC) into intact mice led to marked specific suppression of the immune response of the recipients. The highest suppressive activity was shown by SC taken from donors on the 14th day after intraperitoneal injection of SRBC. The SC of intact animals and of mice receiving a preliminary injection of rat red cells did not affect the immune response of the intact recipients on immunization with SRBC. Treatment of the immune SC with anti-T serum (ATS) or anti-B globulin (ABG) and complement considerably reduced or completely abolished the suppressive activity. Injection of a mixture of two suspensions of immune SC, one treated with ATS and the other with ABG, into intact recipients did not lead to suppression of the immune response. It is postulated that the suppressor cells in this particular model are T lymphocytes, expressing common antigens or antigens cross-reacting with B cells.

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Authors
  1. V. M. Pisarev
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  2. L. A. Pevnitskii
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Pisarev, V.M., Pevnitskii, L.A. Specific suppression of the immune response in the adoptive transfer system. Bull Exp Biol Med 83, 676–679 (1977). https://doi.org/10.1007/BF00800747

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  • DOI: https://doi.org/10.1007/BF00800747

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