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Action of thyroxine on peroxidation of lipids in mitochondrial membranes

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In a concentration higher than 5·10−7 M thyroxine delayed the development of chemiluminescence and reduced the rate of rise of the slow flash. The antioxidative activity of thyroxine was only a little less than the activity of the classical antioxidant α-tocopherol. In lower concentrations (of the order of 1·10−8 M) thyroxine had a peroxidant action, which was most marked in the case of intact mitochondria incubated in phosphate medium in the presence of Mg2+ ions and was weaker in mitochondria treated with Ca2+ ions in hypotonic medium.

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Authors
  1. Yu. A. Vladimirov
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  2. V. M. Gukasov
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  3. V. K. Fedorov
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  4. P. V. Sergeev
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Vladimirov, Y.A., Gukasov, V.M., Fedorov, V.K. et al. Action of thyroxine on peroxidation of lipids in mitochondrial membranes. Bull Exp Biol Med 83, 660–663 (1977). https://doi.org/10.1007/BF00800742

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  • DOI: https://doi.org/10.1007/BF00800742

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