Abstract
The effect of heparin on protein fractions and DNA of isolated hepatocyte nuclei from Wistar rats was studied. Biochemical and cytospectrophotometric tests showed that after exposure to 0.05% sodium heparinate solution 95% of histones were blocked; heparin had no action on the nonhistone proteins of the cell nucleus. Histone blocking was connected with release of DNA from the nuclei into the incubation medium; the quantity of DNA liberated was a linear function of the incubation time.
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Deidenko, O.E., Tsvetkova, S.E. Release of DNA from rat hepatocyte nuclei after treatment with heparin. Bull Exp Biol Med 83, 651–653 (1977). https://doi.org/10.1007/BF00800739
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DOI: https://doi.org/10.1007/BF00800739