Abstract
Incorporation of methionine-S35 into total proteins isolated from various parts of the brain after a single injection of chlorpromazine, majeptil, and trisedil was investigated in experiments on rats. Generalized depression of protein synthesis in all structures except the medulla was observed 1 and 3 h after injection of chlorpromazine. In most experiments majeptil gave a stimulant effect. The action of trisedil was accompanied by reduced incorporation of methionine-S35 into proteins of most brain structures and increased incroporation in the olfactory lobes. It is postulated that changes in protein synthesis in individual brain structures are an important step in the mechanism of action of psychotropic drugs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. A. Korzhov, in: Problems in Experimental Pathology [in Russian], Moscow (1959), p. 253.
L. V. Mitina, Farmakol. i Toksikol., No. 6, 75 (1957).
V. K. Fedorishcheva, On Some Features Distinguishing the Psychopharmacological Action of Majeptil. Author's Abstract of Candidate's Dissertation, Novosibirsk (1971).
L. Abood, Proc. Soc. Exp. Biol. (New York),88, 688 (1955).
H. Albaum and L. Milch, Ann. New York Acad. Sci.,96, 190 (1962).
H. Breitbart, M. Perl, A. Mayevsky, et al., Proc. Soc. Exp. Biol. (New York),143, 204 (1973).
J. Carneiro and A. Cardoso, Experientia,18, 220 (1962).
C. Crifo, A. Bozzi, B. Mondovi, et al., Biochem. Pharmacol.,22, 2511 (1973).
B. Goertz, B. Emmerich, and W. Kersten, Hoppe-Seylers Z. physiol. Chem.,353, 793 (1972).
A. Glasky, Fed. Proc.,22, 272 (1963).
J. Komender, Psychiat. Pol.,3, 355 (1968).
P. Kraus, Europ. J. Pharmacol.,3, 355 (1968).
O. Lindan, J. Quastel, and S. Sved, Canad. J. Biochem.,35, 1145 (1957).
H. Michalek, G. Gatti, and F. Pocciari, Biochem. J.,110, 237 (1968).
N. A. Peterson, C. McKean, and E. Raghupathy, Biochem. Pharmacol.,21, 1275 (1972).
R. Piha, R. Bergström, L. Bergström, et al., Ann. Med. Exp. Fenn.,41, 498 (1963).
L. Safta, B. Cuparencu, and T. Holan, Acta Biol. Med. Germ.,25, 363 (1970).
Y. Takahasi and Y. Akabane, Canad. J. Biochem.,38, 1149 (1960).
Z. Votava and P. Kraus, in: Third International Meeting of the International Society for Neurochemistry, Budapest (1971), p. 268.
J. Yamamoto, A. Tsujimoto, Y. Tsujimura, et al., Jap. J. Pharmacol.,6, 138 (1957).
Rights and permissions
About this article
Cite this article
Maizelis, M.Y. Effect of psychotropic drugs (chlorpromazine, majeptil, trisedil) on protein synthesis in various parts of the rat brain. Bull Exp Biol Med 79, 536–538 (1975). https://doi.org/10.1007/BF00800495
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800495