Abstract
The results of an investigation of the affinity of propranolol, alprenolol, and practolol for β-adrenergic receptors of various organs confirm the division of these receptors into two subtypes. The action of isoprenaline on β1-adrenergic receptors of the smooth muscles of the gastrointestinal tract and myocardium is accompanied by a change in the inflow of Ca++ ions into the cells. Under the influence of isoprenaline on β2-adrenergic receptors of the vessels and trachea an increase in the outflow of Ca++ ions from the cells and a decrease in tone of the smooth muscles are observed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
D. P. Artemenko and M. F. Shuba, Fiziol. Zh. (Ukr), No. 3, 403 (1964).
R. P. Ahlquist, J. Pharm. Sci.,55, 359 (1966).
S. Hagiwara and S. Nakajima, J. Gen. Physiol.,49, 793 (1966).
D. H. Jenkinson, Brit. Med. Bull.,29, 142 (1973).
A. M. Lands, A. Arnold, Z. P. McAuliff, et al., Nature,214, 597 (1967).
B. Levy and B. E. Wilkenfeld, Fed. Proc.,29, 1362 (1970).
F. R. Goodman and G. B. Weiss, Am. J. Physiol.,220, 759 (1971).
H. O. Schild, Brit. J. Pharmacol.,2, 189 (1947).
M. A. Wasserman and B. Levy, J. Pharmacol. Exp. Ther.,182, 236 (1972).
Rights and permissions
About this article
Cite this article
Abramets, I.I., Simon, I.B. Investigation of the nature of differences between β-adrenergic receptors. Bull Exp Biol Med 79, 484–487 (1975). https://doi.org/10.1007/BF00800479
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800479