Abstract
The characteristics of growth of ascites heptoma 22A in the terminal stage of development were studied. It was shown by an autoradiographic method that some cells may be in the G1-or R1-period for 2 or even 4 days. The mean duration of the G2-period was 16 h. Of the total number of cells 55–60% were in the greatly lengthened G1- and R1-period, 7% in the S-period, and 9% in the G2-period. The remaining 25–30% of cells evidently had irreversibly left the mitotic cycle, for they did not participate in proliferation in response to stimulation of cell division.
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Literature Cited
I. D. Belyaeva and T. S. Ivleva, Byull. Éksp. Biol. Med., No. 8, 97 (1974).
I. D. Belyaeva and T. S. Ivleva, Tsitologiya,17, 688 (1975).
I. D. Belyaeva and T. S. Ivleva, Byull. Éksp. Biol. Med., No. 2, 218 (1977).
G. K. A. Andersson and P. T. T. Kjellstrad, Arch. Path. Anat. Abt. B, Zellpath.,16, 311 (1974).
G. K. A. Andersson, J. Cell Physiol.,90, 329 (1977).
P. Bichel and P. Dombernowsky, Cell Tissue Kinet.,6, 359 (1973).
P. Dombernowsky, P. Bichel, and N. Hartmann, Cell Tissue Kinet.,6, 347 (1973).
P. Dombernowsky et al., Cell Tissue Kinet.,7, 47 (1974).
P. Dombernowsky and P. Bichel, Acta Path. Microbiol. Scand. Sect. A,83, 222 (1975).
J. W. Harris, F. Meyskens, and H. M. Patt, Cancer Res.,30, 1937 (1970).
N. R. Hartmann and P. Dombernowsky, Cancer Res.,34, 3296 (1974).
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Ivleva, T.S., Belyaeva, I.D. Characteristics of the mitotic cycle of ascites hepatoma 22A cells in the terminal stage of development. Bull Exp Biol Med 86, 1380–1383 (1978). https://doi.org/10.1007/BF00800465
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DOI: https://doi.org/10.1007/BF00800465