Abstract
Acute resistographic experiments on anesthetized and unanesthetized cats showed that methylapogalanthamine lowers the general arterial pressure and the tone of the cerebral, extracranial, and femoral vessels. The effect on the femoral vessels is the strongest. A biphasic (dilator-constrictor) response was frequently observed. Methylapogalanthamine weakened the constrictor response of the intra- and extracranial vessels to stimulation of the cervical sympathetic nerve. Anesthesia potentiated, whereas rausedil weakened the vasodilator effect of methylapogalanthamine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
E. S. Gabrielyan, Some Aspects of the Physiology and Pharmacology of the Cerebral Circulation [in Russian], Erevan (1976).
M. D. Gaevyi and S. P. Trofimenko, Fiziol. Zh. SSSR, No. 10, 1457 (1970).
M. D. Gaevyi, Fiziol. Zh. SSSR, No. 11, 1677 (1970).
U. B. Zakirov, Kh. U. Aliev, and I. K. Kalimov, Farmakol. Toksikol., No. 6, 708 (1972).
M. D. Mashkovskii, Therapeutic Substances [in Russian], Vol. 1, Moscow (1977), pp. 406–407.
R. S. Mirzoyan, “The pharmacology of adrenergic regulation of the cerebral circulation,” Author's Abstract of Doctoral Dissertation, Moscow (1977).
G. I. Mchedlishvili, Functions of the Vascular Mechanisms of the Brain. Their Role in the Regulation and Pathology of the Cerebral Circulation [in Russian], Leningrad (1968).
G. I. Mchedlishvili, Spasm of the Arteries of the Brain [in Russian], Tbilisi (1977).
V. M. Khayutin, Farmakol. Toksikol., No. 3, 78 (1958).
V. M. Khayutin, Vasomotor Reflexes [in Russian], Moscow (1964), p. 93.
Rights and permissions
About this article
Cite this article
Pogorelyi, V.E., Gaevyi, M.D. Effect of methylapogalanthamine on tone of the cerebral, extracranial, and peripheral vessels. Bull Exp Biol Med 86, 1328–1331 (1978). https://doi.org/10.1007/BF00800449
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800449