Skip to main content
SpringerLink
Log in

The immunogenic properties of some fractions of pasteurella pestis

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

It was established that nucleic acids (NA) ofP. pestis possess a specific property of stimulating the immunity in guinea pigs and monkeys in conjoint administration with the live EB vaccine. Conjoint immunization with the live vaccine and NA protected the animals against experimental bubonic (guinea pigs) and pulmonary plague (monkeys). NA ofP. pestis causes no marked immunity in the animals without the live vaccine. Nucleoprotein (NP) and fraction I ofP. pestis, as well as killed microbes of the EB strain, sodium nucleate, and NA ofBr. melitensis, administered together with the live vaccine caused no stimulating effect on the formation of plague immunity in guinea pigs. Fraction I and NA ofP. pestis, as well as sodium nucleate, obtained from yeast in doses and ratios to the live vaccine, depressed the development of immunity to this injection in guinea pigs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. N. I. Aleksandrov, N. E. Gefen, et al., Active Specific Prophylaxis of Infectious Diseases and Ways of Improving It [in Russian], Moscow, 1962.

  2. N. N. Zhukov-Verezhnikov, Transactions of Rostov-on-Don Plague Research Institute [in Russian], vol. 1, p. 3, 1939.

    Google Scholar 

  3. N. N. Zhukov-Verezhnikov, Zh. mikrobiol., 4–5, 34 (1945).

    Google Scholar 

  4. E. I. Korobkova, Zh. mikrobiol.20, 2, 31 (1938).

    Google Scholar 

  5. E. I. Korobkova, A Living Plague Vaccine [in Russian], Moscow, 1956.

  6. M. P. Pokrovskaya, Vestnik mikrobiologii, épidemiologii i parazitologii, 1, 3 (1934).

    Google Scholar 

  7. M. P. Pokrovskaya, Vestn. mikrobiol., épidemiol. i parazitol., 4, 12 (1934).

    Google Scholar 

  8. M. M. Faibich, Zh. mikrobiol., 6, 32 (1946).

    Google Scholar 

  9. M. M. Faibich and R. V. Korneev, Collected Works of the Research Institute of Epidemiology and Hygiene [in Russian], No. 2, p. 58, Moscow, 1947.

    Google Scholar 

  10. I. A. Chalisov and A. S. Grudenkov, Collected Works of the Research Institute of Epidemiology and Hygiene [in Russian], No. 2, p. 92, Moscow, 1947.

    Google Scholar 

  11. E. E. Baker, H. Sommer, et al., J. Immunol., 1952, v. 68, p. 131.

    Google Scholar 

  12. N. I. Ehrenkanz and F. K. Meyer, J. infect. Dis., 1955, v. 96, p. 138.

    Google Scholar 

  13. W. D. Lawton, G. M. Fukui, and M. J. Surgalla, J. Immunol., 1960, v. 84, p. 475.

    Google Scholar 

  14. M. L. Spivack, L. Foster, A. Larson, et al., Ibid., 1958, v. 80, p. 132.

    Google Scholar 

Download references

Authors
  1. M. M. Faibich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. F. Nepogodin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Korneev
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Faibich, M.M., Nepogodin, N.F. & Korneev, A.A. The immunogenic properties of some fractions of pasteurella pestis. Bull Exp Biol Med 55, 69–72 (1964). https://doi.org/10.1007/BF00800205

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00800205

Keywords

Search

Navigation