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Concentration of renin in the kidneys in experimental hypertension

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the renin content in the kidneys during the development of chronic reflexogenic hypertension in rabbits and in acute experiments for 1.5 hours after section of pressure receptors of the aortic arch and carotid sinuses. The quantitative content of renin in the kidneys was determined by means of biological tests with preliminary conversion of renin into hypertensin. In a chronic course of reflexogenic hypertension no rise in renin content was noted in the kidneys at early periods of development. At the period of stable hypertension (2 to 6 months) a considerable fluctuation of the renal cortex activity was observed in the animals with hypertension. At late periods of hypertension some reduction of the renin content was noted in the kidneys. Removal of pressure receptors of the aortic arch and carotid sinuses in acute experiments changed the content of pressor substances.

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Authors and Affiliations

  1. Laboratory of Physiology of the Circulation, A. A. Bogomolets Institute of Physiology of the Ukrainian SSR Academy of Sciences, Kiev

    M. F. Sirotina

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  1. M. F. Sirotina
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Sirotina, M.F. Concentration of renin in the kidneys in experimental hypertension. Bull Exp Biol Med 55, 30–33 (1964). https://doi.org/10.1007/BF00800195

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  • DOI: https://doi.org/10.1007/BF00800195

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