Abstract
Acute experiments on unanesthetized cats showed that amidopyrine (10 or 20 mg/kg, intravenously) lowers the level of spontaneous unit activity in the thalamic nucleus and leads to grouping of unit discharges and a simultaneous increase in amplitude of focal primary electrical responses. It is suggested that, on the one hand, synchronization of evoked unit responses both in the thalamus and in the cortex, and on the other hand, a lowering of excitability of neurons in the somatosensory projection cortex, participating in interzonal connections, may contribute to the mechanism of action of amidopyrine on the thalamo-cortical level of the somatosensory system.
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Komendantova, M.V., Durinyan, R.A., Glants, V.L. et al. Neurophysiological analysis of the action of amidopyrine on the thalamo-cortical level of the somatosensory system. Bull Exp Biol Med 81, 49–50 (1976). https://doi.org/10.1007/BF00800163
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DOI: https://doi.org/10.1007/BF00800163