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Changes in the acetylcholine-cholinesterase system in the course of experimental botulism

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After injection of type B botulinus toxin into rabbits in a dose of 5000 MLD/kg body weight the acetylcholine content rises both in the CNS (cerebral cortex, spinal cord) and in peripheral organs and tissues (blood, muscles, lungs, diaphragm). After injection of a dose of 25 MLD/kg body weight (the minimal lethal dose) the acetylcholine content rises only in the peripheral organs and tissues. Cholinesterase activity is virtually unchanged during the poisoning. It is postulated that the changes in the acetylcholine-cholinesterase system take place because of the effect of the toxin on the secretion of acetylcholine.

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Authors
  1. S. G. Khotenko
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  2. V. I. Goncharova
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Khotenko, S.G., Goncharova, V.I. Changes in the acetylcholine-cholinesterase system in the course of experimental botulism. Bull Exp Biol Med 81, 30–32 (1976). https://doi.org/10.1007/BF00800157

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  • DOI: https://doi.org/10.1007/BF00800157

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