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Comparative immunogenicity of irradiated and nonirradiated syngeneic and xenogeneic tumor cells containing a common specific transplantation antigen

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The immunogenic activity of native and irradiated syngeneic and xenogeneic tumor cells, carrying a common transplantation antigen specific for SV40 on their surface, was compared in Syrian hamsters. The results showed that syngeneic tumor cells were more immunogenic for the recipient than xenogeneic tumor cells containing antigen of the same specificity. Irradiation makes tumor cells, including xenogeneic cells, more immunogenic, possibly on account of the ability of the unirradiated cells to escape recognition on account of their ability to divide.

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Klyuchareva, T.E., Kashkina, L.M. & Deichman, G.I. Comparative immunogenicity of irradiated and nonirradiated syngeneic and xenogeneic tumor cells containing a common specific transplantation antigen. Bull Exp Biol Med 86, 1087–1089 (1978). https://doi.org/10.1007/BF00799600

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  • DOI: https://doi.org/10.1007/BF00799600

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