Abstract
Hydrallazine (2.5 mg/kg), obsidan (10 mg/kg, and promethazine (10 mg/kg) increased the NAD+NADH content in the liver and brain of intact rats without affecting their relative proportions. These drugs, in the same doses, especially if administered together, raised the NAD+NADH level if depressed by hypoxia and increased the NAD/NADH ratio. It is concluded that the antihypoxic action of hydrallazine, obsidan, and promethazine is perhaps connectd with an increase in the total nicotinamide-adenine dinucleotide content and a relative increase in the content of its oxidized form.
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Abakumov, G.Z., Lukienko, P.I. Effect of hydrallazine, obsidan, and promethazine and their combinations on the nad and nadh content in the liver and brain of hypoxic rats. Bull Exp Biol Med 86, 1046–1047 (1978). https://doi.org/10.1007/BF00799586
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DOI: https://doi.org/10.1007/BF00799586