Abstract
Reserpine-like substances were found to be synthesized in homogenates, microsomes, and cytosol from various human and animal tissues with the utilization of acetate, methyl groups of S-adenosylmethionine, tryptophan, reserpine, etc., as precursors. It is suggested that endogenous reserpine-like substances participate in the autoregulation of the levels of free and bound biogenic amines.
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Literature Cited
P. P. Garyaev, A. M. Vikhert, and Yu. S. Petrenko, Byull. Éksp. Biol. Med., No. 7, 35 (1977).
H. S. Alpers and P. A. Shore, Biochem. Pharmacol.,18, 1363 (1969).
P. U. Angeletti and R. Levi-Montalcini, Proc. Nat. Acad. Sci. USA,69, 85 (1972).
A. Carlsson, N. A. Hillarp, and B. Waldeck, Med. Exp. (Basel),6, 47 (1962).
A. Giachetti, R. A. Hollenbeck, and P. A. Shore, Naunyn-Schmiederberg's Arch. Pharmacol.,263, 283 (1974).
N. Kirshner, J. Biol. Chem.,273, 2311 (1962).
R. J. Morin, E. E. Edralin, and J. M. Woo, Atherosclerosis,27, 39 (1974).
S. Norn and P. A. Shore, Biochem. Pharmacol.,20, 1291 (1971).
L. A. Wagner and R. E. Stitzel, J. Pharm. Pharmacol.,24, 396 (1972).
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Garyaev, P.P., Vikhert, A.M. & Zakharkina, G.A. Biosynthesis of reserpine-line substances in the myocardium and other tissues of man and animals. Bull Exp Biol Med 86, 1023–1025 (1978). https://doi.org/10.1007/BF00799579
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DOI: https://doi.org/10.1007/BF00799579