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Induction of postural asymmetry in an intact recipient by brain extract from a donor with the same syndrome

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

An attempt was made at the direct transfer of postural asymmetry, following removal of half the anterior lobe of the cerebellum in rats, to a recipient. Asymmetry of the hind limbs was shown to appear in spinal animals after injection of brain extract of pathological donors into their subdural space below the level of transection. The specificity of the resulting asymmetry depending on the side of injury to the donor's cerebellum was revealed. The asymmetry of the recipient completely copied the asymmetry of the donor. Brain extracts from control animals did not induce asymmetry. Additional confirmation was obtained of the polypeptide nature of the factor stimulating the development of postural asymmetry. Treatment of the extract with pronase deprived it of its activity.

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Authors
  1. G. A. Vartanyan
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  2. Yu. V. Balabanov
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Vartanyan, G.A., Balabanov, Y.V. Induction of postural asymmetry in an intact recipient by brain extract from a donor with the same syndrome. Bull Exp Biol Med 86, 996–999 (1978). https://doi.org/10.1007/BF00799571

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  • DOI: https://doi.org/10.1007/BF00799571

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