Functional interaction between determinant and other foci of epileptiform activity created bilaterally in the cortex

Abstract

Experiments on cats anesthetized with pentobarbital showed that on the creation of a hyperactive focus with a high level of excitation in the orbital or coronary cortex and a series of foci in the opposite neocortex a functional complex is formed, which works to the same program determined by the activity of the hyperactive focus. The latter plays the role of a determinant structure. Depression of activity of the determinant focus by pentobarbital leads to disinte-gration of the epileptic complex. Division of the rostral portion of the corpus callosum led to disturbance of synchronized operation of the determinant and other foci of epileptic activity. The results confirm the general concept of the role of determinant structures in the activity of the nervous system.