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A Model of Activity Generation in the Epileptic Focus

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Abstract

A model of activity generation in the epileptic focus was proposed based on the ideas that synchronization occurs between the oscillations that arise to regulate the resting potential level and that neuronal discharges are synchronized with slow oscillations. Four phases were identified in seizure development: an increase in slow-wave activity, high-frequency spike activity, synchronization in the presence of sharp peaks, and extinction of the seizure. The model was compared with an intraoperative electrocorticography record.

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ACKNOWLEDGMENTS

I am grateful to N.A. Arkhipova, L.B. Ivanov, A.B. Kozlova, M.A. Kulikov, V.I. Luk’yanov, L.B. Oknina, K.Yu. Sarkosova, M.Yu. Chelyapina, and E.V. Sharova for help and valuable comments.

Funding

This work was supported by the Russian Foundation for Basic Research (project no. 18-013-00967a).

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Authors and Affiliations

  1. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of the Russian Federation, 125047, Moscow, Russia

    E. L. Masherov

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  1. E. L. Masherov
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Correspondence to E. L. Masherov.

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Conflict of interests. The author declares that he has no conflict of interest.

This work does not contain any studies involving animals or human subjects performed by the author.

Additional information

Translated by T. Tkacheva

Abbreviations: EEG, electroencephalogram.

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Masherov, E.L. A Model of Activity Generation in the Epileptic Focus. BIOPHYSICS 66, 665–670 (2021). https://doi.org/10.1134/S0006350921040114

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  • DOI: https://doi.org/10.1134/S0006350921040114

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