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Free glutamine content and glutaminase activity in the gastric mucosa of patients with precancerous diseases and carcinoma of the stomach

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The free glutamine content and phosphate-dependent glutaminase activity were determined in biopsy specimens of tissue from gastric polyps, malignant tumors, and ulcers and the surrounding mucosa from patients with precancerous diseases and with carcinoma of the stomach. The glutamine coneent in the carcinomas was not significantly different from that in normal gastric mucosa. The glutamine level in areas of mucosa remote from the tumor was considerably higher than normally. Gastric polyposis was characterized by absence of glutamine in the mucosa outside the lesion. Marked glutaminase activity was found in the carcinomas, but its level was indistinguishable from normal or from that in patients with precancerous diseases.

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Authors
  1. L. S. Aptekar'
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Aptekar', L.S. Free glutamine content and glutaminase activity in the gastric mucosa of patients with precancerous diseases and carcinoma of the stomach. Bull Exp Biol Med 82, 1385–1387 (1976). https://doi.org/10.1007/BF00799485

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  • DOI: https://doi.org/10.1007/BF00799485

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