Abstract
Cocaine, a serotonin M antagonist and dihydroergotamine, a D antagonist, considerably inhibited the uptake of serotonin by human platelets (by 90 and 62% respectively in a concentration of 10−4 M). The M antagonist of serotonin, morphine, its D antagonist deseryl, and the T antagonist tipindole inhibited serotonin uptake by a much lesser degree (by 33, 28, and 18% respectively in a concentration of 10−4 M). It is postulated that the “serotonin” center of the membrane carrier participating in the transmembrane transport of serotonin is not identical with any one particular type of serotonin receptor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. B. Dolgo-Saburov and G. F. Oksenkrug, Farmakol. Toksikol., No. 6, 698 (1974).
V. V. Zakusov, Vestn. Akad. Med. Nauk SSSR, No. 7, 43 (1968).
G. F. Oksenkrug, Byull. Éksp. Biol. Med., No. 8, 74 (1975).
G. F. Oksenkrug, Byull. Éksp. Biol. Med., No. 1, 61 (1976).
I. N. Pidevich, “Pharmacological characteristics of serotoninergic structures of a new type,” Author's Abstract of Doctoral Dissertation, Moscow (1972).
H. R. Baumgartner and G. V. R. Born, Nature,218, 137 (1968).
G. V. R. Born et al., Brit. J. Pharmacol.,44, 117 (1972).
F. Michal, Nature,221, 1253 (1969).
A. Pletscher, Brit. J. Pharmacol.,32, 1 (1968).
P. M. Seeman, Internat. Rev. Neurobiol.,9, 145 (1966).
J. M. Sneddon, Prog. Neurobiol.,1, Part 2, 153 (1973).
E. Solatunturi, Ann. Med. Exp. Biol. Fenn.,46, 435 (1968).
G. F. Oxenkrug (G. F. Oksenkrug) and A. H. Staib, Acta Biol. Med. Ger.,33, 253 (1974).
W. Wesemann, in: Biochemistry of Sensory Function, New York (1974), p. 565.
Rights and permissions
About this article
Cite this article
Oksenkrug, G.F. Effect of D-, M-, and T antagonists of serotonin on its uptake by human platelets. Bull Exp Biol Med 82, 1347–1348 (1976). https://doi.org/10.1007/BF00799471
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00799471