Abstract
The rate of passage through the first mitotic cycle by ascites hepatoma 22A cells of different ages after the stimulation of division was studied. “Aging” (11 days old), terminal (14 days), and “delayed” (4 days older than terminal) ascites fluid was used. The highest values of the index of labeled nuclei (due mainly to the transition from the resting state of the cells into the S period) were found to occur toward 9–12 h, and of the mitotic index toward 18–21 h after transplantation regardless of the age of the tumor. It follows from these results that the duration both of the prereplicative (G1) period and of the whole of the first mitotic cycle after stimulation of division is independent of the duration of stay of the ascites hepatoma 22A cells in the resting state (or the very protracted G1 period).
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Belyaeva, I.D., Ivleva, T.S. Rate of passage through the first mitotic cycle by ascites hepatoma 22A cells of different ages after stimulation of division. Bull Exp Biol Med 83, 236–238 (1977). https://doi.org/10.1007/BF00799433
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DOI: https://doi.org/10.1007/BF00799433