Abstract
Mice of various inbred lines were immunized intradermally withClostridium oedematiens α toxoid. The immunization was repeated 30 days later. The titer of antibodies against toxoid was determined by the passive hemagglutination test in the blood of the mice 20 and 30 days after the first and 10 days after the second immunization. The maximal response to primary immunization was recorded in C3H mice, the minimal in DBA/2 mice, with a more than 30-fold difference. The remaining tested lines of mice (A, CBA, BALB/c, AKR, C57BR) occupied an intermediate position. After the second immunization the differences were reduced. The existence of genetic control of the immune response to this particular antigen is postulated in mice.
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Translated from Byullenten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 2, pp. 198–200, February, 1977.
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Petrov, R.V., Panteleev, É.I., Moshiashvili, I.Y. et al. Immune response of mice of various inbred lines toClostridium oedematiens toxoid. Bull Exp Biol Med 83, 208–210 (1977). https://doi.org/10.1007/BF00799425
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DOI: https://doi.org/10.1007/BF00799425